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目的观察儿童接种3剂甲乙型肝炎联合疫苗后的乙肝加强免疫效果,为乙肝加强预防接种的实施提供依据。方法于2009年9月采用整群抽样方法,在玉环县抽取已完成乙肝基础免疫、未加强接种且乙肝感染标志物均阴性的6~9岁儿童123名,按照“0-1-6”程序接种3剂甲乙型肝炎联合疫苗,并于加强接种1年和5年后分别检测乙肝病毒表面抗体(抗-HBs)浓度。结果加强接种1年和5年后分别检测102和82人,抗-HBs阳性率分别为92.16%和78.05%,差异有统计学意义(P<0.05)。5年随访的82名儿童加强接种前、1年和5年的抗-HBs浓度分别为2.95、141.76和72.13 m IU/m L,差异有统计学意义(P<0.01);不同出生年份儿童抗-HBs浓度差异无统计学意义(P>0.05);检测时间与出生年份存在交互作用(P<0.05)。结论对乙肝疫苗基础免疫后抗-HBs转阴的6~9岁儿童采用3剂甲乙型肝炎联合疫苗进行加强接种,乙肝免疫效果较好。
Objective To observe the effect of boosting hepatitis B after 3 doses of hepatitis A and B vaccine in children and provide the basis for strengthening hepatitis B vaccination. METHODS: A total of 123 children aged 6 ~ 9 years old who had not been inoculated and whose HBV markers were negative were collected from Yuhuan County in September 2009 using cluster sampling method. According to "0-1-6 The program was inoculated with three doses of hepatitis A and B combined vaccine and tested for hepatitis B virus surface antibody (anti-HBs) concentrations at 1 year and 5 years after vaccination. Results The positive rates of anti-HBs were 92.16% and 78.05% in 102 and 82 patients after intensive vaccination for 1 year and 5 years respectively. The difference was statistically significant (P <0.05). The anti-HBs concentrations of 82 children before 5-year follow-up were 2.95, 141.76 and 72.13 m IU / m L respectively before vaccination, the difference was statistically significant (P <0.01); Children born at different birth years -HBs concentration had no significant difference (P> 0.05); there was interaction between test time and birth year (P <0.05). Conclusions Hepatitis B vaccination with 3 doses of hepatitis B vaccine is effective for 6 to 9 years old children who have anti-HBs negative after HBsAg immunization.