论文部分内容阅读
胸腺在T细胞发育方面的中枢作用,经廿多年的研究已经证实.研究T-系列细胞在胸腺内发育的细胞学及分子生物学机理,可以用正常有胸腺动物进行,另外也可用无胸腺纯系裸鼠(athymic nude mice,nu/nu)进行,以探讨在无胸腺条件下是否有T细胞存在,及引导发育的机理.裸鼠的突变表现为胚胎发育期颈囊(外胚层结构)不发育,在胚胎第12-13天时,胸腺只剩一厚纤维囊,而无淋巴样前体细胞存在.正常小鼠此时的胸腺内,则有淋巴样
Thymus in the T cell development in the central role, after more than 20 years of research has confirmed.Study T-series cells in the thymus developmental cytology and molecular biology, can be used to normal thymus animals, the other can also be azygous Athymic nude mice (nu / nu) were used to investigate the existence of T cells in athymic conditions and to guide the development of the mechanism.Nuclear mutations in nude mice showed that the cervical capsule (ectoderm structure) during embryonic development was not Development, in the embryos on the first 12-13 days, the thymus only a thick fibrous capsule, but no lymphoid precursor cells exist in the normal mouse thymus, there are lymphoid