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目的:研究补阳壮骨方对雌性自然衰老大鼠骨密度及骨小梁的影响。方法:取11月龄雌性SD大鼠,正常饲养至11.5月龄时开始给药,连续给药4个月。观察补阳壮骨方对雌性自然衰老大鼠骨密度及骨小梁的影响。结果:补阳壮骨方可一定程度上防止自然衰老引起的骨密度下降;能改善自然衰老引起的骨小梁结构退化。结论:补阳壮骨方对自然衰老导致的雌性大鼠骨密度及骨小梁退变有一定的预防作用。
Objective: To study the effect of Buyang Zhuanggu Prescription on BMD and trabecular bone of female rats with natural aging. METHODS: Eleven-month-old female Sprague-Dawley rats were administrated at the age of 11.5 months and continued for 4 months. Observe the effect of Buyang Zhuanggu Prescription on BMD and trabecular bone in female natural aging rats. RESULTS: Buyang Zhuanggu Prescription can prevent the decrease of bone density caused by natural aging to a certain extent; it can improve the degradation of trabecular bone caused by natural aging. Conclusion: Buyang Zhuanggufang has certain preventive effect on bone density and trabecular bone degeneration in female rats caused by natural aging.