论文部分内容阅读
目的:探讨细胞因子与重症急性胰腺炎发病机理的关系。方法:采用双抗体夹心法ELISA检测重症急性胰腺炎病人发病第1、3、7天血清中IL-1β,IL-6和TNF-α的含量。结果:重症急性胰腺炎病人血清中3种细胞因子的含量均显著高于对照组,并于第3天时达高峰,第7天时随病情的好转而下降,但仍高于对照组。结论:重症急性胰腺炎的发病与IL-1β,IL-6和TNF-α等3种细胞因子的升高有关。
Objective: To investigate the relationship between cytokines and pathogenesis of severe acute pancreatitis. Methods: The levels of IL-1β, IL-6 and TNF-α in sera of patients with severe acute pancreatitis at the 1st, 3rd, 7th day after onset were detected by double antibody sandwich ELISA. Results: Serum levels of the three cytokines in patients with severe acute pancreatitis were significantly higher than those in the control group, reaching the peak on the third day and decreasing with the improvement of the disease on the seventh day, but still higher than that of the control group. Conclusion: The incidence of severe acute pancreatitis is related to the increase of three cytokines, such as IL-1β, IL-6 and TNF-α.