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关于化学物对雄性生殖系统的损害已有不少研究报道。早在六十年代初期,动物实验就已发现二溴氯丙烷(DBCP)对睾丸有损害作用。Whorton等(1977年)首次报道了DBCP生产工人不育,并发现DBCP接触者精子减少或无精。近年来,化学物对雄性生殖系统的毒性研究愈来愈受到重视,除不断采用各种新技术外,在寻求快速、灵敏的生殖毒物检测方法方面进展也很快。本文主要介绍目前正在应用和逐步发展起来的一些雄性生殖毒理评价方法。
There have been many reports on the damage of chemicals to the male reproductive system. As early as the early 1960s, animal experiments have found that dibromochloropropane (DBCP) has a damaging effect on the testes. For the first time, Whorton et al. (1977) reported sterility in DBCP-producing workers and found that sperm were reduced or undefinished in DBCP-exposed individuals. In recent years, more and more attention has been paid to the toxicity of chemicals to the male reproductive system. In addition to continuous application of various new technologies, rapid progress has been made in the search for rapid and sensitive detection methods for reproductive toxins. This article mainly introduces some male reproductive toxicology evaluation methods that are currently being applied and gradually developed.