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TNF和IL-1等一类炎症前细胞因子的过量产生在败血性综合征的发病机制中发挥重要作用。近几年来发现几种内源性蛋白质可影响炎症前细胞因子的产生或其活性。可溶性IL-1 Ⅱ型受体可结合IL-1,但不激发细胞反应,是IL-1活性的负性调节因子。IL-10和IL-13均能够抑制内毒素诱导的各种炎症细胞因子的产生。本文对42例败血症病人进行了连续3d血浆可溶性IL-1 Ⅱ型受体、IL-10和IL-13浓度的测定,并对健康人注射内毒素后上述介质出现的情况进行了观察。 42名确诊为败血症的病人。19名正常对
Overproduction of pre-inflammatory cytokines, such as TNF and IL-1, play an important role in the pathogenesis of septic syndrome. In recent years, several endogenous proteins have been found to affect the production of pro-inflammatory cytokines or their activities. Soluble IL-1 type II receptors bind to IL-1 but do not stimulate cellular responses and are negative regulators of IL-1 activity. Both IL-10 and IL-13 are able to inhibit endotoxin-induced production of various inflammatory cytokines. In this paper, 42 cases of sepsis patients were measured for 3 days plasma soluble IL-1 type II receptor, IL-10 and IL-13 concentrations were measured, and healthy people after injection of endotoxin in the above media were observed. 42 patients diagnosed with sepsis. 19 normal pair