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目的探讨藻酸双酯钠（ＰＳＳ）对肺炎病儿细胞黏附分子表达的影响。②方法采用ＥＬＩＳＡ法，检测了应用ＰＳＳ治疗前后肺炎病儿外周血白细胞ＣＤ１８的表达、血清可溶性细胞间黏附分子－１（ｓＩＣＡＭ－１）和可溶性血管细胞间黏附分子－１（ｓＶＣＡＭ－１）浓度的变化。③结果肺炎病儿外周血白细胞ＣＤ１８表达、ｓＩＣＡＭ－１和ｓＶＣＡＭ－１浓度明显增高，与对照组比较差异均有极显著性（ｔ＝６．２７０～９．８８２，Ｐ均＜０．００１）。应用ＰＳＳ治疗后白细胞ＣＤ１８表达、ｓＩＣＡＭ－１和ｓＶＣＡＭ－１明显降低，与治疗前和普通治疗组比较差异均有极显著意义（ｔ＝７．５５２～６９．９３０，Ｐ均＜０．００１）。④结论ＰＳＳ能明显降低肺炎病儿细胞黏附分子表达。
Objective To investigate the effect of sodium alginate (PSS) on the expression of cell adhesion molecules in children with pneumonia. Methods The expression of CD18 on peripheral blood leukocytes in children with pneumonia was detected by ELISA. The levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) The change. Results The CD18 expression in peripheral blood leukocytes of children with pneumonia was significantly higher than that of the control group (t = 6.270-9.882, P <0.001), and the levels of sICAM-1 and sVCAM- . After treatment with PSS, CD18 expression, sICAM-1 and sVCAM-1 in leukocytes were significantly decreased (all P <0.001, t = 7.552 ~ 69.930, P < . ④ Conclusion PSS can significantly reduce the expression of cell adhesion molecules in children with pneumonia.