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目的 探讨前列腺素E1(PGE1)预处理对急性心肌梗塞的早期和延迟保护作用。方法 ivPGE1(2 5mg·kg-1和15 0mg·kg-1)对大鼠进行预处理 ,分别于预处理后 2 0min或 2 4hip异内肾上腺素 (80mg·kg-1)造成急性心肌梗塞 ,于ip异丙肾上腺素后 2 4h取出心脏、匀浆 ,测定其丙二醛(MDA)含量 ,谷胱甘肽过氧化物酶 (GSH Px)活性 ,总超氧化物歧化酶 (T SOD)和锰 超氧化物歧化酶 (Mn SOD)活性。结果 心肌梗塞模型组心肌MDA含量明显上升 ,GSH Px活性降低 ,T SOD和Mn SOD活性增高。与模型组比较 ,两剂量PGE1预处理后 2 0min及 2 4h的各组均明显降低梗塞心肌的MDA含量 (P <0 0 1)和T SOD、Mn SOD活性 (均P<0 0 1) ,提高GSH Px活性 (P <0 0 1)。结论 前列腺素E1预处理具有预适应性早期和延迟心肌保护作用。
Objective To investigate the early and delayed protection of prostaglandin E1 (PGE1) pretreatment on acute myocardial infarction. Methods The rats were pretreated with ivPGE1 (25mg · kg-1 and 150mg · kg-1), respectively. The rats were inflicted with acute myocardial infarction at 20 min or 24 h intra-epinephrine (80 mg · kg- The hearts were homogenized 24 h after ip isoproterenol and the contents of malondialdehyde (MDA), glutathione peroxidase (GSH Px), total superoxide dismutase (T SOD) and Manganese superoxide dismutase (Mn SOD) activity. Results The myocardial MDA content increased obviously, the activity of GSH Px decreased and the activity of T SOD and Mn SOD increased in myocardial infarction model group. Compared with the model group, the MDA content (P <0.01) and the activities of T SOD and Mn SOD in infarcted myocardium were significantly decreased in both groups at 20 min and 24 h after pretreatment with two doses of PGE1 (all P <0.01) Increase GSH Px activity (P <0.01). Conclusions Prostaglandin E1 preconditioning has early and delayed myocardial protection.