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目的探究不同剂量阿托伐他汀降脂治疗老年冠心病临床效果。方法选择我院收治的70例老年冠心病患者,随机抽签分为两组,观察组接受阿托伐他汀20mg/d治疗,对照组接受阿托伐他汀10mg/d治疗,比较两组临床治疗效果、血脂水平。结果治疗后观察组患者三酰甘油(1.5±0.3)mmol/L、高密度脂蛋白胆固醇(1.4±0.1)mmol/L、低密度脂蛋白胆固醇(1.8±0.4)mmol/L、总胆固醇(3.1±0.3)mmol/L显著优于对照组水平,组间差异具有统计学意义(P<0.05)。观察组临床治疗有效率(94.3%)显著高于对照组(77.1%),组间比较差异具有统计学意义(P<0.05)。观察组2例患者出现不良反应,几率为(5.7%);对照组1例患者出现不良反应,不良反应几率为(2.9%);组间比较差异无统计学意义(P>0.05)。结论与10mg/d剂量相比,20mg/d阿托伐他汀降脂治疗老年冠心病效果显著,值得临床推广。
Objective To investigate the clinical effects of different doses of atorvastatin on lipid lowering in elderly patients with coronary heart disease. Methods 70 elderly patients with coronary heart disease admitted to our hospital were randomly divided into two groups. The observation group received atorvastatin 20 mg / d, the control group received atorvastatin 10 mg / d. The clinical effects of the two groups were compared , Blood fat level. Results After treatment, triglyceride (1.5 ± 0.3) mmol / L, high density lipoprotein cholesterol (1.4 ± 0.1) mmol / L, low density lipoprotein cholesterol (1.8 ± 0.4) mmol / L and total cholesterol ± 0.3) mmol / L was significantly better than the control group, the difference between the two groups was statistically significant (P <0.05). The effective rate of clinical treatment in observation group (94.3%) was significantly higher than that in control group (77.1%). The difference between the two groups was statistically significant (P <0.05). Adverse reactions were observed in 2 patients in the observation group, with a 5.7% chance of adverse reactions. One patient in the control group had adverse reactions with a rate of adverse reactions of 2.9%. There was no significant difference between the two groups (P> 0.05). Conclusion Compared with 10mg / d dose, 20mg / d atorvastatin lipid-lowering treatment of elderly patients with coronary heart disease is significant, worthy of clinical promotion.