论文部分内容阅读
用线性扫描极谱法研究盐酸二甲双胍的电化学行为。在pH6.85的0.1mol·L-1磷酸氢二钠-磷酸二氢钾缓冲溶液中,盐酸二甲双胍于-1.165V(vs.SCE)处产生一灵敏的吸附波,其一次微分线性扫描峰电流与盐酸二甲双胍质量浓度在0.41～41.0mg·mL-1范围内呈线性关系,检出限(3S/N)为0.28mg·mL-1。对41.0mg·mL-1盐酸二甲双胍溶液进行6次平行试验,相对标准偏差(n=6)为0.72%。此方法已用于测定其片剂中盐酸二甲双胍的含量。
Study of Electrochemical Behavior of Metformin Hydrochloride by Linear Sweep Polarography. In pH6.85 0.1mol · L-1 disodium hydrogen phosphate - potassium dihydrogen phosphate buffer solution, metformin hydrochloride at -1.165V (vs.SCE) produce a sensitive adsorption wave, the first differential linear sweep peak current And metformin hydrochloride concentration range of 0.41 ~ 41.0mg · mL-1 within a linear relationship, the detection limit (3S / N) was 0.28mg · mL-1. Six replicates of the metformin hydrochloride solution at 41.0 mg · mL -1 were run in parallel with a relative standard deviation (n = 6) of 0.72%. This method has been used to determine the content of metformin hydrochloride in its tablets.