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目的探讨脑电功率谱分析方法用于无创颅内压(ICP)监测的可行性。方法选择2008年9月-2009年5月62例(70例次)中枢神经系统疾病住院患者,腰椎穿刺测定ICP,同时采集脑电信号,利用自行研制的软件进行脑电功率谱定量分析,计算压力指数(PI)。结果 62例患者ICP为70~500 mm H2O(1 mm H2O=0.009 8 k Pa),平均(239.74±116.25)mm H2O其中52.9%的患者ICP增高。PI为0.02~0.85,平均0.29±0.20。取每个患者的ICP值与PI,行Spearman等级相关分析显示,二者呈负相关(rs=-0.849,P<0.01)。将患者分为弥漫性脑损害组和局灶性脑损害组,分别行相关性分析,结果示两组患者PI与ICP之间均呈负相关(rs=-0.815、-0.912,P值均<0.01)。结论通过脑电信号分析得到的PI与ICP具有相关性,提示脑电功率谱分析方法用于无创ICP监测具有可行性,值得进一步研究。
Objective To explore the feasibility of noninvasive intracranial pressure (ICP) monitoring by EEG power spectrum analysis. Methods From September 2008 to May 2009, 62 patients (70 times) with central nervous system diseases were selected as inpatients. Lumbar puncture ICP was performed and EEG signals were collected simultaneously. EEG power spectrum was quantitatively analyzed by self-developed software to calculate pressure Index (PI). Results The ICP of 62 patients was 70 ~ 500 mm H 2 O (1 mm H 2 O = 0.009 8 k Pa), with an average of (239.74 ± 116.25) mm H 2 O. PI was 0.02 to 0.85 with an average of 0.29 ± 0.20. The ICP and PI of each patient were analyzed by Spearman rank correlation analysis, the two were negatively correlated (rs = -0.849, P <0.01). Patients were divided into diffuse brain damage group and focal brain damage group, respectively, correlation analysis was performed, the results showed that there was a negative correlation between PI and ICP (rs = -0.815, -0.912, P < 0.01). Conclusion The correlation between PI and ICP obtained through EEG analysis suggests that the EEG analysis method is feasible for noninvasive ICP monitoring and warrants further investigation.