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目的探讨芹菜素、根皮苷、原花青素和新橙皮苷二氢查尔酮等黄酮类化合物在CCl4诱导的小鼠肝纤维化模型中的抗肝纤维化作用。方法将♂昆明种小鼠105只随机均分为正常对照组、CCl4模型组、秋水仙碱组、芹菜素组、根皮苷组、原花青素组、新橙皮苷二氢查尔酮组。给药5周后采血并处死小鼠,测定并比较各组小鼠血清中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)的活性,总蛋白(TP)、白蛋白(ALB)及肝组织中的羟辅氨酸(HYP)的含量,计算小鼠的肝指数,观察肝脏的病理变化。结果 4种黄酮类化合物均可使模型小鼠血清中ALT、AST的含量、肝组织中羟脯氨酸的含量降低;病检也证明各组小鼠的肝细胞变性、坏死和肝纤维化均有不同程度的减轻。结论芹菜素、根皮苷、原花青素及新橙皮苷二氢查尔酮有抗CCl4致小鼠肝纤维化的作用。
Objective To investigate the anti-hepatic fibrosis effect of flavonoids such as apigenin, phlorizin, proanthocyanidin and neohesperidin dihydrochalcone in CCl4-induced mouse hepatic fibrosis model. Methods 105 male Kunming mice were randomly divided into normal control group, CCl4 model group, colchicine group, apigenin group, phlorizin group, procyanidin group and neohesperidin dihydrochalcone group. After 5 weeks of administration, the mice were sacrificed and the mice sacrificed. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), white Protein (ALB) and the content of hydroxy-HA in liver tissue (HYP). The liver index of mice was calculated and the pathological changes of the liver were observed. Results All the four flavonoids could decrease the levels of ALT and AST and the content of hydroxyproline in the liver of the model mice. The pathological examination also showed that the hepatocytes degeneration, necrosis and liver fibrosis Have different degrees of relief. Conclusion Apigenin, phlorizin, proanthocyanidin and neohesperidin dihydrochalcone have anti-CCl4-induced liver fibrosis in mice.