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胰岛素抵抗是2型糖尿病(DM)主要的致病机制之一。2002年以来,我们对初发2型DM患者检测血浆抵抗素(R)水平,并与单纯肥胖人群比较,以探讨R在2型DM致病机制中的作用。 临床资料:根据1998年WHO新的DM诊断标准,选择初发未经治疗的2型DM患者60例,按体重指数(BMI)=体重(kg)/身高(m)~2,将入选患者分组。A组30例(BMI<25),年龄(43.6±6.9)岁;B组30例(BMI≥25),年龄(44.8±7.1)岁。对照组C组为BMI≥25的单纯肥胖者30例,年龄(41.2±7.8)岁,空腹血糖<6.1mmol/L,餐后2小时血糖<
Insulin resistance is one of the major pathogenic mechanisms of type 2 diabetes mellitus (DM). Since 2002, we measured plasma resistin (R) levels in patients with newly diagnosed type 2 DM and compared them with those in obese individuals to investigate the role of R in the pathogenesis of type 2 DM. Clinical data: According to the new diagnostic criteria of WHO in 1998, 60 patients with untreated type 2 DM were selected, and the patients were divided into groups according to the body mass index (BMI) = body weight (kg) / height (m) . A group of 30 patients (BMI <25), age (43.6 ± 6.9) years; B group 30 patients (BMI ≥ 25), age (44.8 ± 7.1) years. In the control group, 30 simple obesity patients with BMI≥25, age (41.2 ± 7.8) years, fasting blood glucose <6.1mmol / L, postprandial blood glucose <