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目的:观察三化汤及其组方对脑缺血再灌注老龄大鼠胃肠组织TXB2、6-Keto-PGF1α含量的影响。方法:将大鼠随机分为正常组、模型组、三化汤组、西药组(尼莫地平)、中成药组(血栓心脉宁)。采用双侧颈总动脉结扎方法制备老龄大鼠脑缺血模型,脑缺血1h后,再灌注0.5h。取每组大鼠胃体部组织和小肠组织各5~20mg制成匀浆,分别测定TXB2和6-Keto-PGF1α的含量。结果:三化汤组、血栓心脉宁组及尼莫地平组均能显著降低胃肠组织TXB2含量(P<0.01,P<0.05)、显著升高6-Keto-PGF1α含量(P<0.01,P<0.05),且三化汤组优于其他两用药组(P<0.05)。结论:三化汤对脑缺血再灌注老龄大鼠胃肠组织损伤有较好的保护作用。
OBJECTIVE: To observe the effect of Sanhua Decoction and its preparation on the content of TXB2, 6-Keto-PGF1α in the gastrointestinal tissue of aged rats with cerebral ischemia-reperfusion. METHODS: Rats were randomly divided into normal group, model group, Sanhua Decoction group, western medicine group (nimodipine) and Chinese patent medicine group (thrombosis Xinmaining). The model of cerebral ischemia in aged rats was prepared by bilateral common carotid artery ligation. After cerebral ischemia for 1 h, reperfusion was performed for 0.5 h. Each group of rat stomach body tissue and small intestine tissue were made of 5 ~ 20mg homogenate, were determined TXB2 and 6-Keto-PGF1α content. Results: Sanhuatang Decoction, Xueshuan Xinmaining Decoction and nimodipine group all significantly reduced the content of TXB2 in gastrointestinal tissues (P<0.01, P<0.05), and significantly increased the content of 6-Keto-PGF1α (P<0.01, P<0.05), and Sanhua Decoction group was superior to other dual-use drugs (P<0.05). Conclusion: Sanhua Decoction has a good protective effect on gastrointestinal tissue damage in aged rats with cerebral ischemia-reperfusion.