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中枢性抗高血压药实验,是心血管药物的重要实验。以往多采用椎动脉给药,观察药物的中枢性降压作用,手术比较复杂,学生操作不易成功。为此,我们在1981年设计出“可乐宁中枢降压作用原理分析”实验。该实验是由家兔静脉及侧脑室注射可乐宁,观察对血压的影响,而后分别注射α_1受体阻断剂和α_1受体阻断剂,观察对可乐宁降压作用的影响,以初步分析可乐宁降压作用原理。该实验手术操作简单,家兔侧脑室注射部位标记明确,易于掌握。经过五年的实践证明效果良好。
Central anti-hypertensive drugs experiment is an important experiment of cardiovascular drugs. Vertebral artery in the past to use more drugs to observe the central role of antihypertensive drugs, surgery is more complicated and difficult for students to operate successfully. To this end, we designed in 1981, “Ke Laning central hypotonic principle analysis” experiment. In this experiment, the rabbit venules and lateral ventricle injection of clonidine, observed the impact on blood pressure, and then injection of α 1 receptor blockers and α 1 receptor blockers, observe the effect of koilon antihypertensive effect to a preliminary analysis Clonidine hypotensive principle. The experimental operation is simple, rabbit lateral ventricle injection site marked clear, easy to grasp. After five years of practice proved effective.