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目的 :观察肾综合征出血热 (HFRS)乳鼠脑纯化Ⅰ型灭活疫苗在浙江省HFRS高发疫区大面积人群接种后的安全性 ,考核血清学及近期、中期流行病学效果。方法 :采用间接免疫荧光法 (IFAT)检测特异性IgG抗体 ,用微量细胞病变中和试验 (MCPENT)检测中和抗体滴度。结果 :共接种 10 4 6 0人 ,全程接种者占 97.30 % ,对照 16 159人。全程接种后两周进行血清学观察 ,荧光抗体阳转率为 10 0 .0 0 % (6 7/ 6 7) ,中和抗体阳转率为 4 4 .4 4 % ,几何平均滴度分别为 72 .12和 4 .6 2。1年后加强免前、免后两周和免后 1年 ,荧光抗体阳性率分别为 2 8.57%、83.33%、75.0 0 % ;中和抗体阳性率分别为 14.80 %、55.56 %、35.0 0 %。疫苗近期 (基础免疫后 1年 )和中期 (基础免疫后 2年 )流行病学防病效果良好 ,人群保护率达 10 0 %。目前未发现接种人群中有免疫 (感染 )增强问题。结论 :HFRS疫苗近期和中期流行病学防病效果明显 ,取得良好的经济和社会效益
Objective: To observe the safety of type Ⅰ inactivated purified brain vaccine of neonatal hemorrhagic fever with renal syndrome (HFRS) in a large area of HFRS high incidence in Zhejiang Province, and to evaluate serological and short-term and mid-term epidemiological effects. Methods: Specific IgG antibodies were detected by indirect immunofluorescence (IFAT) and neutralizing antibody titers were detected by MCPENT. Results: A total of 10 4600 people were vaccinated, 97.30% of them were vaccinated and 16 159 were control subjects. Serological observation was performed two weeks after inoculation. The positive rate of fluorescent antibody was 100.0% (67/67) and the positive rate of neutralizing antibody was 44.44%. The geometric mean titers were 72.12 and 4.2.6 After 1 year, the positive rates of fluorescent antibody were 28.57%, 83.33% and 75.0% respectively, the positive rates of neutralizing antibody were 14.80%, 55.56%, 35.0%. Vaccines Epidemiology Preventive effects are good in the near future (1 year after basic immunization) and in the middle period (2 years after basic immunization), and the population protection rate is 10%. No immunization (infection) enhancement has been found in vaccinated populations. Conclusion: The epidemic prevention effect of HFRS vaccine in the short and medium term is obvious, and has achieved good economic and social benefits