目的　观察帕米膦酸二钠 (APD)治疗恶性肿瘤骨转移性疼痛的疗效。方法　 2 4例均应用帕米膦酸二钠治疗 ,首次 6 0mg加入生理盐水 5 0 0ml静滴 ,3～ 4小时滴完 ,每 2周重复 30mg ,共重复 2次 ,总量 12 0mg。结果　总有效率 (CR +PR)为 83 3 % ,总完全缓解率 (CR)为 5 8 3 %。对 1级、2级、3级疼痛的有效率分别为 10 0 %、6 6 7%、33 3 % ;完全缓解率分别为 80 0 %、33 3 %、0 %。结论　APD对恶性肿瘤骨转移性疼痛的疗效高 ,且疗效与疼痛程度呈负相关 Objective To observe the efficacy of pamidronate disodium (APD) in the treatment of malignant bone metastases. Methods 24 cases were treated with pamidronate disodium, the first 60mg added saline 500ml intravenous drip 3 to 4 hours, repeated every 2 weeks 30mg, a total of two repeated, the total 120mg. Results The total effective rate (CR + PR) was 83.3% and the total complete remission rate (CR) was 58.3%. The effective rates of grade 1, grade 2 and grade 3 pain were 100%, 667% and 333% respectively; the complete remission rates were 80 0%, 33 3% and 0% respectively. Conclusion APD is highly effective in treating bone metastatic pain of malignant tumors and its efficacy is negatively correlated with the degree of pain