论文部分内容阅读
目的 :调查不孕 (育 )症夫妇弓形虫感染水平 ,探讨弓形虫感染与不孕 (育 )症的关系。 方法 :随机选择苏州市吴中区不孕 (育 )症夫妇 178对 ,对其血清进行弓形虫感染和抗精子抗体及抗心磷脂抗体ELISA检测 ,并选择相应地区的正常健康生育夫妇 190对作为对照。 结果 :178对不孕 (育 )症夫妇弓形虫感染阳性家庭 6 2对 ,占不孕(育 )症家庭的 34.83% ,其中男性弓形虫感染阳性 30例 ,感染率为 16 .85 % ;女性弓形虫感染阳性 5 0例 ,感染率为2 8.0 9% ,均显著高于对照组相应的弓形虫感染率 12 .11%、6 .32 %、7.89% (P <0 .0 1)。弓形虫感染阳性病人的抗精子抗体阳性率为 32 .5 0 % ,显著高于弓形虫感染阴性病人中的抗体阳性率 15 .94 % (χ2 =10 .76 ,P <0 .0 1) ,相对危险比 (OR)为 2 .5 4。而两组中抗心磷脂抗体阳性率差异无显著性 (χ2 =1.6 3,P >0 .0 5 )。 结论 :弓形虫感染与不孕不育确有某种联系 ,弓形虫感染与抗精子抗体的产生可能有关联 ,它可能涉及不育 (孕 )症的致病机制
Objective: To investigate the infection level of Toxoplasma gondii in couples with infertility (infertility) and explore the relationship between Toxoplasma gondii infection and infertility (infertility). Methods: 178 pairs of infertile couples were randomly selected in Wuzhong District of Suzhou City. Toxoplasma gondii infection and anti-sperm antibody and anti-cardiolipin antibody were used to detect the sera. 190 normal healthy couples Control. Results: Of the 178 infertile couples, 62 were positive for Toxoplasma gondii infection, accounting for 34.83% of the infertility families, of which 30 were male toxoplasmosis, with an infection rate of 16.85%. Women Toxoplasma infection was found in 50 cases with an infection rate of 2 8.09%, which were all significantly higher than those of the control group (12.11%, 6.32%, 7.89%, P <0.01). The positive rate of anti-sperm antibodies in patients with Toxoplasma gondii infection was 32.5%, significantly higher than that in Toxoplasma infection patients 15.94% (χ2 = 10.76, P <0.01) The relative hazard ratio (OR) was 2.54. There was no significant difference in the positive rate of anti-cardiolipin antibodies between the two groups (χ2 = 1.6 3, P> 0.05). CONCLUSIONS: Toxoplasma infection has some connection with infertility. Toxoplasma infection may be associated with the production of anti-sperm antibodies, which may be related to the pathogenesis of infertility