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目的观察α-硫辛酸(ALA)治疗糖尿病周围神经病变(DPN)的临床疗效。方法将120例DPN患者随机分为2组,对照组60例予甲钴胺静滴治疗,治疗组60例予ALA静滴治疗,疗程2周。观察两组治疗前后临床症状、体征、FBG、HbA_1c、血浆内皮素(ET)、尿白蛋白(UAlb)和C反应蛋白(C-RP)水平变化,以及运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)。结果治疗组治疗后MNCV、SNCV上升作用与对照组相仿,而血ET、血C-RP、UAlb均下降,疗效明显优于对照组,差异均有统计学意义。结论 ALA治疗DPN临床疗效明显优于甲钴胺。
Objective To observe the clinical efficacy of α-lipoic acid (ALA) in the treatment of diabetic peripheral neuropathy (DPN). Methods 120 cases of DPN patients were randomly divided into two groups, the control group of 60 patients treated with intravenous mecobalamin, 60 patients in the treatment group were treated with ALA intravenously for 2 weeks. The changes of clinical symptoms, signs, FBG, HbA 1c, plasma ET, UAb and C-reactive protein (C-RP) Conduction speed (SNCV). Results After treatment, MNCV and SNCV in the treatment group were similar to those in the control group, while the levels of ET, C-RP and UAlb in the treatment group decreased significantly. The curative effect was obviously superior to that in the control group. The differences were statistically significant. Conclusion The clinical efficacy of ALA in the treatment of DPN is obviously better than that of mecobalamin.