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目的 :观察含有卡铂、透明质酸钠、人体清蛋白的卡铂复合液在胃癌、大肠癌切除术后腹腔内化疗中的抗腹腔粘连和腹膜纤维化作用。方法 :胃癌、大肠癌切除术后患者随机分为卡铂液组和卡铂复合液组 ,比较两组患者在第 2次手术时腹腔内粘连发生率和粘连程度 ,腹膜纤维化发生率和纤维化程度 ;采用寿命表分析法比较术后复发转移率。结果 :卡铂复合液腹腔内化疗可明显降低腹腔内粘连程度和粘连发生率 (P<0 .0 1) ,减少腹膜纤维化程度和纤维化发生率 (P<0 .0 1) ,癌肿切除术后采用卡铂复合液腹腔内化疗患者术后复发转移率明显低于卡铂液组。结论 :卡铂复合液可明显地抑制腹腔内化疗中常见的腹腔粘连和腹膜纤维化 ,明显提高对癌细胞杀伤作用。采用卡铂复合液腹腔内化疗是胃肠道癌肿切除后预防复发、转移的一种安全、有效方法。
Objective: To observe the anti-peritoneal adhesions and peritoneal fibrosis effects of carboplatin-containing complexes containing carboplatin, sodium hyaluronate, and human albumin in intraperitoneal chemotherapy after resection of gastric cancer and colorectal cancer. Methods: Patients with gastric cancer and colorectal cancer resection were randomly divided into carboplatin group and carboplatin group. The incidence and adhesion degree of intraperitoneal adhesions, the incidence of peritoneal fibrosis, and fiber were compared between the two groups during the second operation. Degree of life; the use of life table analysis to compare the rate of postoperative recurrence and metastasis. RESULTS: Intraperitoneal chemotherapy with carboplatin solution significantly reduced the degree of intra-abdominal adhesions and adhesions (P < 0.01), and reduced the degree of peritoneal fibrosis and fibrosis (P < 0.01). Postoperative recurrence and metastasis rate of patients treated with intraperitoneal chemotherapy with carboplatin was significantly lower than carboplatin group. Conclusion: Carboplatin complex can significantly inhibit the intraperitoneal adhesions and peritoneal fibrosis commonly seen in intraperitoneal chemotherapy, and significantly enhance the killing effect on cancer cells. Intraperitoneal chemotherapy with carboplatin is a safe and effective method for preventing recurrence and metastasis after excision of gastrointestinal cancer.