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目的探讨亚麻醉剂量氯胺酮与丙泊酚在无痛人流中的麻醉效果。方法选取2013年8月—2015年8月丰县中医院收治的无痛人流患者80例,随机分为对照组与观察组,各40例。对照组患者给予丙泊酚人流术前麻醉,观察组患者给予亚麻醉剂量氯胺酮与丙泊酚进行麻醉,比较两组患者麻醉前、麻醉后2min、麻醉后10min平均动脉血压(MAP)、心率(HR)和血氧饱和度(Sp O_2)水平以及苏醒时间、丙泊酚用量、门诊观察时间,观察两组患者不良反应发生情况。结果两组患者麻醉前MAP、HR和Sp O_2水平比较,差异有统计学意义(P>0.05);麻醉后2min观察组患者MAP、HR、Sp O_2与麻醉前比较,差异无统计学意义(P>0.05);麻醉后2min对照组患者MAP、HR低于麻醉前,差异有统计学意义(P<0.05);麻醉后2min对照组患者Sp O_2与麻醉前比较,差异无统计学意义(P>0.05);两组患者麻醉后2min MAP、HR比较,差异有统计学意义(P<0.05);两组患者麻醉后2min Sp O_2比较,差异无统计学意义(P>0.05);麻醉后10min两组患者MAP、HR和Sp O_2比较,差异无统计学意义(P>0.05)。观察组患者丙泊酚总用量少于对照组,差异无统计学意义(P<0.05);两组患者苏醒时间、门诊观察时间比较,差异无统计学意义(P>0.05)。观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论亚麻醉剂量氯胺酮与丙泊酚应用于无痛人流的麻醉中效果明显,对患者心血管功能影响较小,且不良反应少。
Objective To investigate the anesthetic effect of sub-anesthetic ketamine and propofol in painless abortion. Methods Eighty patients with painless abortion admitted in Fengxian Hospital of Chinese Medicine from August 2013 to August 2015 were randomly divided into control group and observation group, 40 cases each. The patients in the control group were given propofol anesthesia before anesthesia. The patients in the observation group were anesthetized with sub-anesthetic ketamine and propofol. Before anesthesia, 2 minutes after anesthesia, 10 minutes after anesthesia, mean arterial pressure (MAP) and heart rate HR) and oxygen saturation (Sp O_2) levels, as well as the recovery time, the dosage of propofol and the time of outpatient observation. The incidence of adverse reactions in both groups were observed. Results The MAP, HR and Sp O 2 levels before anesthesia in the two groups were significantly different (P> 0.05). There was no significant difference in MAP, HR and Sp O 2 between the two groups after anesthesia > 0.05). MAP and HR in patients in the control group 2 minutes after anesthesia were lower than those before anesthesia (P <0.05). There was no significant difference in Sp O 2 between the patients in the control group 2 minutes after anesthesia and before anesthesia (P> 0.05). There were significant differences in MAP and HR between the two groups at 2 min after anesthesia (P <0.05). There was no significant difference in Sp O 2 between the two groups 2 min after anesthesia (P> 0.05) Group MAP, HR and Sp O 2, the difference was not statistically significant (P> 0.05). The total amount of propofol in the observation group was less than that of the control group, with no significant difference (P <0.05). There was no significant difference between the two groups in the recovery time and out-patient observation time (P> 0.05). The incidence of adverse reactions in observation group was lower than that in control group, the difference was statistically significant (P <0.05). Conclusion The sub-anesthetic dose of ketamine and propofol is effective in painless anesthesia and has little effect on cardiovascular function and less adverse reactions.