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自福建产中药海风藤(Piper kadsura (Choisy)Ohwi)的藤茎中又分得5个苯骈呋喃类新木脂素,经光谱分析(UV,IR,MS,NMR,CD)和衍生物制备,确定化合物Ⅱ和Ⅴ为新结构。Ⅱ为化合物denudatin B的对映体,命名为(-)-denudatin B,V为7S,8S-3,4,3′-三甲氧基-7′-氧-缺8′,9′-7.O.4,′8.5′-新木脂素,命名为风藤素M(kadsurenin M)。化合物Ⅰ,Ⅲ和Ⅳ分别为已知化合物海风藤酮(Ⅰ),(-)-acuminatin(Ⅲ)和(+)-licarin A(Ⅳ)。PAF受体结合实验证明,(-)-denudatin B也具有较强的PAF拮抗活性。
Five benzoquinone furanoic lignans were obtained from the canes of Fujian Piper kadsura (Choisy) Ohwi, and were analyzed by spectroscopic analysis (UV, IR, MS, NMR, and CD) and derivatives. Confirm that compounds II and V are new structures. II is the enantiomer of the compound denudatin B, designated (-)-denudatin B, V is 7S, 8S-3,4,3’-trimethoxy-7’-oxygen-deficient 8’, 9’-7. O.4, ’8.5’-neolignan, named kadsurenin M. Compounds I, III and IV are the known compounds, epineoide (I), (-)-acuminatin (III) and (+)-picarin A (IV), respectively. PAF receptor binding experiments demonstrated that (-)-denudatin B also has strong PAF antagonistic activity.