论文部分内容阅读
1.乙胺碘呋酮与地高辛:因为血浆地高辛浓度增高和乙胺碘呋酮的剂量及其血浆浓度有关。地高辛主要由肾排出,给予乙胺碘呋酮后,血浆地高辛浓度增高可能与肾对地高辛的排出降低有关。其机制可能是地高辛在体内的分布极不均衡,某些组织中的浓度甚至可超过血浆的100倍,但乙胺碘呋酮与组织的亲和力更强,合并用药后,乙胺碘呋酮将组织中地高辛置换出来,使血浆中地高辛含量增加,易导致地高辛中毒,甚至可导致
1. Amiodarone and digoxin: Because plasma digoxin concentrations increased and the dose of amiodarone and its plasma concentration. Digoxin is mainly excreted by the kidneys. After giving amiodarone, the increase of plasma digoxin concentration may be related to the decreased renal excretion of digoxin. The mechanism may be digoxin distribution in the body is extremely uneven, the concentration in some tissues even more than 100 times the plasma, but amiodarone and tissue affinity is stronger, after the combination of drugs, Ketone will be replaced by tissue digoxin, plasma digoxin levels increased, easily lead to digoxin poisoning, and may even lead