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氨基糖苷类抗生素由于其肾脏毒性和耳前庭毒性严重限制了其临床使用,而肾中毒的发病机理与其肾皮质内药物蓄积的程度有关。为了探求预防措施,作者对25名肿瘤部分累及单侧肾且肾功正常准备作肾切除术的患者,进行了单剂短程30分钟和24小时连续输注相同剂量药物的对比研究,以研究两种给药方案对肾脏皮质内药物蓄积的影响。受试者年龄不超过70岁,血清肌酸酐浓度在0.9和1.2mg/dl之间,在术前24小时随机给予庆大霉素4.5mg/kg或乙基西索米星5mg/kg并按同等剂量将两药分二个治疗组给药:
Aminoglycoside antibiotics severely limit their clinical use because of their renal toxicity and vestibular vestibuli toxicity, whereas the pathogenesis of renal toxicity is related to the degree of drug accumulation in the renal cortex. To explore preventive measures, the authors performed a single-dose, 30-minute, and 24-hour continuous infusion of the same dose of drug in a study of 25 patients with partially neoplastic renal involvement and normal kidney function for nephrectomy to study two Effects of Different Dosage Regimens on Drug Accumulation in Renal Cortex. Subjects were not older than 70 years of age, serum creatinine concentrations were between 0.9 and 1.2 mg / dl, and gentamicin 4.5 mg / kg or ethyl sisomicin 5 mg / kg was given randomly 24 hours prior to surgery The same dose of two drugs administered to two treatment groups: