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本文测定１８例放置甲地孕酮硅橡胶阴道环发生突破性出血妇女外周血及子宫内膜组织中６—酮—前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）与血栓素（ＴＸＢ２）含量，以２１例放甲硅环未发生出血妇女及２１例未放环妇女为对照。结果表明：各组外周血Ｅ２和Ｐ水平无显著差异。使用甲硅环发生突破性出血（ＢＴＢ）者外周血中６－ｋｅｔｏ－ＰＧＦ１α、ＴＸＢ２合量及６—ｋｅｔｏ－ＰＧＦ１α／ＴｘＢ２比值在增殖期明显高于放环未出血组及正常组。发生ＢＴＢ者子宫内膜组织中６－ｋｅｔｏ－ＰＧＦ１α明显高于未出血组。提示：前列腺素在甲硅环所致ＢＴＢ中有一定作用。本文结果还表明，应用炔雌醇和萘普生治疗ＢＴＢ，其有效率分别为９１．１％和７６．７％，提示除６—ｋｅｔｏ－ＰＧＦ１α和ＴＸＢ２参与引起ＢＴＢ外，雌二醇可能也是ＢＴＢ发生的部分机制之一。
In this paper, the content of 6-keto-PGF1α and TXB2 in peripheral blood and endometrial tissue of 18 patients with breakthrough hemorrhage caused by megestrol silicone vaginal ring were measured. Cases of silicone ring bleeding did not occur in women and 21 cases of non-ring women as a control. The results showed that: E2 and P levels in peripheral blood of each group had no significant difference. The amount of 6-keto-PGF1α, TXB2 and the ratio of 6-keto-PGF1α / TxB2 in peripheral blood of patients with breakthrough hemorrhage (BTB) in the Si ring were significantly higher than those in the untreated and normal group. The incidence of 6-keto-PGF1α in endometrial tissue of patients with BTB was significantly higher than that of non-bleeding group. Tip: prostaglandins in the silicon ring caused by BTB have a role. Our results also show that ethinyl estradiol and naproxen treatment of BTB, the effective rates were 91.1% and 76.7%, suggesting that in addition to 6-keto-PGF1α and TXB2 involved in causing BTB, estradiol may also be BTB One of the mechanisms that happened.