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32例得到冠状动脉造影(CAG)证实并发NSTEMI的2型糖尿病患者入院后0.5h、24h、48h、72h、96h行血清TnⅠ、肌酸激酶同工酶(CK-MB)水平检测,观察主要心血管事件(包括非致死性再次心肌梗死和心脏性病死,MACE)。结果:TnⅠ、CK-MB检测诊断NSTEMI的灵敏度在48~72h达到高峰,TnⅠ诊断NSTEMI的灵敏度(62.5%~87.5%)明显高于CK-MB(31.3%~43.8%)(P<0.05或P<0.01);住院期和随访期TnⅠ阳性组的MACE发生率分别为35%、29.4%,明显高于TnⅠ阴性组(分别为0、0)(χ2=6.45,4.26,P<0.05)。结论:TnⅠ检测对2型糖尿病并发NSTEMI诊断与MACE的预测均有重要的临床价值。
Thirty-two patients with type 2 diabetes confirmed by coronary angiography (CAG) and NSTEMI were examined for serum TnⅠ and CK-MB levels at 0.5h, 24h, 48h, 72h and 96h after admission. Vascular events (including non-fatal recurrent myocardial infarction and cardiac death, MACE). Results: The sensitivity of TnⅠ and CK-MB in diagnosis of NSTEMI peaked at 48-72h. The sensitivity of TnⅠ in diagnosing NSTEMI was significantly higher than that in CK-MB (31.3% -43.8%) (P <0.05 or P <0.01). The incidence of MACE during hospitalization and follow-up in TnⅠpositive group was 35% and 29.4% respectively, which was significantly higher than that in TnⅠnegative group (χ2 = 6.45,4.26, P <0.05). Conclusion: Tn Ⅰ detection of type 2 diabetes complicated with NSTEMI diagnosis and MACE have important clinical value.