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通过支气管肺泡灌洗（ＢＡＬ）从１５例慢性支气管炎缓解期病人和１１例正常人获得的肺泡巨噬细胞（ＡＭ）加入重组人白细胞介素Ⅱ（ｒＩＬ－２）１０００Ｕ／ｍｌ及ＬＰＳ１μｇ／ｍｌ体外培养２４ｈ。结果两组ＡＭ合成分泌的ＴｘＢ２和６－ｋｅｔｏ－ＰＧＦ１α明显升高（Ｐ＜０．０５）；两组间ＡＭ合成分泌的ＴＮＦα和６－ｋｅｔｏ－ＰＧＦ１α均呈显著差异性（Ｐ＜０．０５）。说明ｒＩＬ－２促进ＡＭ的活化，可能对慢性支气管病人呼吸道Ｔｈ１细胞功能相对受抑有一定代偿作用。
Alveolar macrophages (AM) obtained from 15 patients with chronic bronchitis and 11 normal controls were treated with recombinant human interleukin II (rIL-2) 1000 U / ml and LPS 1 μg / ml by bronchoalveolar lavage (BAL) Cultured in vitro 24h. Results The levels of TxB2 and 6-keto-PGF1α secreted by AM were significantly increased in both groups (P <0.05), while TNFα and 6-keto-PGF1α secreted by AM were significantly different between the two groups ). This suggests that rIL-2 can promote the activation of AM and may be compensated for the relative inhibition of Th1 cell function in the respiratory tract of patients with chronic bronchitis.