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通过支气管肺泡灌洗(BAL)从15例慢性支气管炎缓解期病人和11例正常人获得的肺泡巨噬细胞(AM)加入重组人白细胞介素Ⅱ(rIL-2)1000U/ml及LPS1μg/ml体外培养24h。结果两组AM合成分泌的TxB2和6-keto-PGF1α明显升高(P<0.05);两组间AM合成分泌的TNFα和6-keto-PGF1α均呈显著差异性(P<0.05)。说明rIL-2促进AM的活化,可能对慢性支气管病人呼吸道Th1细胞功能相对受抑有一定代偿作用。
Alveolar macrophages (AM) obtained from 15 patients with chronic bronchitis and 11 normal controls were treated with recombinant human interleukin II (rIL-2) 1000 U / ml and LPS 1 μg / ml by bronchoalveolar lavage (BAL) Cultured in vitro 24h. Results The levels of TxB2 and 6-keto-PGF1α secreted by AM were significantly increased in both groups (P <0.05), while TNFα and 6-keto-PGF1α secreted by AM were significantly different between the two groups ). This suggests that rIL-2 can promote the activation of AM and may be compensated for the relative inhibition of Th1 cell function in the respiratory tract of patients with chronic bronchitis.