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目的分析骨髓形态联合血清肿瘤标志物检测对淋巴瘤诊断及预后的意义。方法选取2014年1月—2016年4月丰城市人民医院收治的确诊为淋巴瘤患者44例为观察组,选取同期本院健康体检者45例为对照组。两组受试者均行骨髓细胞形态学检验、电化学发光法检测多种肿瘤标志物,对比分析检测结果。结果观察组癌胚抗原(CEA)、癌抗原125(CA125)、癌抗原15-3(CA15-3)、血清铁蛋白(SF)水平高于对照组,差异有统计学意义(P<0.05);两组癌抗原19-9(CA19-9)、癌抗原724(CA724)、细胞角蛋白片断21-1(CYRA21-1)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌抗原(SCC)水平比较,差异无统计学意义(P>0.05)。观察组中骨髓浸润患者CEA、CA125、CA15-3、SF水平高于骨髓未浸润患者,差异有统计学意义(P<0.05)。结论骨髓形态联合血清肿瘤标志物检测能够对淋巴瘤的诊断、病情以及是否合并骨髓浸润提供可靠的参考依据,进而为临床治疗方案的选择和实施提供参考。
Objective To analyze the significance of detection of bone marrow combined with serum tumor markers in the diagnosis and prognosis of lymphoma. Methods Forty-four patients diagnosed as lymphomas in Fengcheng People’s Hospital from January 2014 to April 2016 were selected as the observation group, and 45 healthy subjects in the same period were selected as the control group. Two groups of subjects underwent bone marrow cell morphometry, electrochemiluminescence detection of a variety of tumor markers, comparative analysis of test results. Results The levels of CEA, CA125, CA15-3 and SF in the observation group were significantly higher than those in the control group (P <0.05) ; Two groups of cancer antigen 19-9 (CA19-9), cancer antigen 724 (CA724), cytokeratin 21-1 (CYRA21-1), neuron specific enolase (NSE), squamous cell carcinoma antigen (SCC) levels, the difference was not statistically significant (P> 0.05). The CEA, CA125, CA15-3 and SF levels in patients with bone marrow infiltration in the observation group were significantly higher than those in patients without bone marrow infiltration (P <0.05). Conclusion The detection of bone marrow combined with serum tumor markers can provide a reliable reference for the diagnosis of lymphoma, the condition of patients and the infiltration of bone marrow, and provide a reference for the selection and implementation of clinical treatment options.