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目的探讨酮康唑致不良反应(ADR)的类型及特点,为临床合理用药提供参考。方法对1994年以来国内公开发行的医药期刊报道的酮康唑致ADR共48例进行分类统计、分析。结果ADR临床主要表现为肝胆系统损害(15.5%)、全身性损害(14.4%)、胃肠系统损害(13.4%)、中枢及外周神经系统损害(10.1%)、皮肤及其附件损害(7.2%)等。结论临床应重视酮康唑的ADR,合理选用抗真菌药物。
Objective To explore the types and characteristics of ketoconazole-induced adverse reactions (ADRs) and to provide a reference for clinical rational drug use. Methods A total of 48 cases of ADR induced by ketoconazole reported in the domestic pharmaceutical journals published since 1994 were classified and analyzed. Results The main clinical manifestations of ADR were hepatobiliary system injury (15.5%), general injury (14.4%), gastrointestinal system injury (13.4%), central and peripheral nervous system damage (10.1%), skin and its attachment damage )Wait. Conclusion Clinical should pay attention to the ADR of ketoconazole, rational use of antifungal agents.