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32例鼻咽癌患者淋巴细胞BP诱发的SCE高于13例对照(p<0.001),与先前的结果一致。有两个证据提示对BP诱发SCE的敏感性和遗传因素有密切关系:1.19对鼻咽癌患者与其一级亲属配对间BP诱发的SCE显著相关(p<0.05),但类似的相关关系不存在于13对患者与其配偶之间(p>0.2);2.BP诱发的SCE在家系内有聚集的倾向,而在7个家系间则有明显的差异(p<0.05)。 19例散发鼻咽癌患者一级亲属BP诱发SCE与对照无显著差异(p>0.1),但27例鼻咽癌家系的非癌患者成员则显著高于对照(p<0.01),特别是患者及其同胞的子代(p<0.001)。这些结果与对BP诱发SCE的敏感性和对鼻咽癌的易感性之间可能有关的观点相符。
In 32 patients with nasopharyngeal carcinoma, lymphocyte BP-induced SCE was higher than that of 13 controls (p<0.001), which was consistent with previous results. Two lines of evidence suggest that the sensitivity to BP-induced SCE is closely related to hereditary factors: 1.19 is significantly associated with BP-induced SCE between nasopharyngeal cancer patients and their first-degree relatives (p<0.05), but similar correlations do not exist There were 13 pairs of patients and their partners (p>0.2); 2.BP-induced SCE had a tendency to accumulate in the family, but there were significant differences among the 7 families (p<0.05). There was no significant difference in BP-induced SCE between first-degree relatives of 19 patients with nasopharyngeal carcinoma and controls (p>0.1), but 27 patients with non-cancer patients of nasopharyngeal carcinoma family were significantly higher than the control (p<0.01), especially patients. Progeny of their siblings (p<0.001). These results are consistent with a possible relationship between the sensitivity to BP-induced SCE and the susceptibility to nasopharyngeal cancer.