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A new method to determine the concentration of amikacin(AMK)using methyl blue(MB)as electrochemical probe was developed in this paper.In pH 4.5 Britton-Robinson(B-R)buffer solution,the MB reacted with AMK to form ion association complexes,which led to the reductive peak current of MB at-0.275 V(versus SCE)to decrease,and the decreases were linear with the concentration of AMK in the range of 1.0-60.0 mg/L,the regression of equation isΔIp(nA)=-8.48+102.36c(mg/L), correlation coefficientγis 0.997.The conditions for determining the concentration of AMK using linear sweep voltammetry(SLV) were optimized.The method was used to determine the content of amikacin commercially available with satisfactory results.
A new method to determine the concentration of amikacin (AMK) using methyl blue (MB) as electrochemical probe was developed in this paper. PH 4.5 Britton-Robinson (BR) buffer solution, the MB reacted with AMK to form ion association complexes, which led to the reductive peak current of MB at-0.275 V (versus SCE) to decrease, and the decreased were linear with the concentration of AMK in the range of 1.0-60.0 mg / L, the regression of equation is ΔIp (nA) = -8.48 + 102.36c (mg / L), correlation coefficientγis 0.997. These conditions for determining the concentration of AMK using linear sweep voltammetry (SLV) were optimized. The method was used to determine the content of amikacin commercially available with satisfactory results.