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目的 :探讨p3 3 ING1基因蛋白与胃癌发生及病理生物学关系及临床意义。方法 :对 71例胃癌、12例胃粘膜不典型增生、18例对照组 ,应用Envision免疫组化法 ,检测p3 3 ING1。结果 :粘膜不典型增生组及对照组中p3 3 ING1均阳性表达 ,而胃癌中表达 62 .0 % (44 / 71)有明显下降 ,与前两组之间有显著差异 (P <0 .0 1) ;胃癌中p3 3 ING1表达与肿瘤的浸润、淋巴结的转移及分化有关 (P <0 .0 1)。结论 :p3 3 ING1是抑癌基因 ,在胃癌中表达下降 ,对胃癌发生、发展可能起重要作用 ,p3 3 ING1与p5 3野生型基因互相协同、依赖 ,抑制细胞生长、促进凋亡。p3 3 ING1的水平 ,对p5 3介导的基因治疗尤为重要 ,应予检测。
Objective: To investigate the relationship between p3 3 ING1 gene protein and the occurrence and pathological biology of gastric carcinoma and its clinical significance. Methods: Envision immunohistochemistry was used to detect p3 3 ING1 in 71 cases of gastric cancer, 12 cases of gastric dysplasia, and 18 cases of control group. RESULTS: The expression of p3 3 ING1 was positive in the mucosal atypical hyperplasia group and the control group, while the expression of 62.0% (44/71) in the gastric cancer was significantly decreased, which was significantly different from the previous two groups (P < .0 1) The expression of p3 3 ING1 in gastric cancer was related to tumor invasion, lymph node metastasis and differentiation (P < 0.01). Conclusion : p3 3 ING1 is a tumor suppressor gene and its expression is decreased in gastric cancer. It may play an important role in the occurrence and development of gastric cancer. p3 3 ING1 and p53 wild-type genes cooperate and depend on each other to inhibit cell growth and promote apoptosis. The level of p3 3 ING1 is particularly important for p53-mediated gene therapy and should be tested.