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目的探讨有氧运动对高脂膳食金黄地鼠糖脂代谢及过氧化物酶增殖体受体(PPARs)的影响。方法将健康雄性清洁级金黄地鼠20只随机分为对照组和运动组,每组10只。2组金黄地鼠均给予质量分数10%高脂膳食。运动组金黄地鼠做跑台运动10周,对照组未做跑台运动。10周后检测金黄地鼠生物化学指标及肝脏组织中PPARs的基因表达。结果有氧运动10周后,2组金黄地鼠血清三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇比较差异无统计学意义(P>0.05);运动组金黄地鼠空腹血糖、胰岛素水平明显低于对照组,差异有统计学意义(P<0.05,P<0.01);有氧运动可以金黄地鼠提高肝脏总胆固醇、肝脂酶、脂蛋白脂酶(LPL)水平(P<0.05);2组金黄地鼠血清、肝脏、肌肉及肾周脂肪中游离脂肪酸比较差异无统计学意义(P>0.05);有氧运动升高金黄地鼠肝脏PPARs不明显(P>0.05)。结论有氧运动对高脂膳食金黄地鼠肝脏PPARs影响不明显,但可以调节糖脂代谢,降低血糖及胰岛素水平,改善胰岛素抵抗。
Objective To investigate the effects of aerobic exercise on glucose and lipid metabolism and peroxisome proliferator-activated receptors (PPARs) in high-fat diets of golden hamster. Methods Twenty healthy male clean golden hamsters were randomly divided into control group and exercise group, with 10 rats in each group. 2 groups of golden hamsters were given 10% of high-fat diet. Exercise group hamster doing treadmill exercise for 10 weeks, the control group did not do treadmill exercise. After 10 weeks, the biochemical indexes of golden hamster and the gene expression of PPARs in liver tissue were detected. Results After 10 weeks of aerobic exercise, serum triglyceride, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol in two groups of hamsters showed no significant difference (P> 0.05) (P <0.05, P <0.01). Aerobic exercise increased the levels of total cholesterol, hepatic lipase and lipoprotein lipase (LPL) in the liver of the hamster P <0.05). There were no significant differences in serum, liver, muscle and perirenal fat between the two groups (P> 0.05), while the aerobic exercise increased the hepatic PPARs of the hamster (P> 0.05) ). Conclusion Aerobic exercise has no obvious effect on the liver PPARs of high-fat diet hamsters, but it can regulate the metabolism of glucose and lipids, lower blood glucose and insulin levels, and improve insulin resistance.