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目的:探讨母婴循环血中趋化素趋化素与母亲血脂、肾功能及新生儿出生体重的关系。方法:选取妊娠期糖尿病(gestational diabetes mellitus,GDM)患者63例及健康对照64例,检测母血和脐带血趋化素、母血脂、肌酐、尿素氮、尿酸等指标。结果:GDM组母血及脐血趋化素、母亲总胆固醇(TC)和甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)均显著高于对照组(P均<0.05),脐血趋化素与新生儿出生体重呈正相关(r=0.456,P<0.001);多元回归分析显示,新生儿出生体重(β=0.221,P=0.012)、脐血趋化素(β=0.289,P=0.001)、母甘油三酯(β=0.348,P=0.001)、高密度脂蛋白胆固醇(HDL-C,β=-0.279,P<0.001)、肌酐(β=0.260,P=0.001)与母血趋化素独立相关。结论:GDM母亲血趋化素与脐血趋化素相关;且脐血中较高浓度的趋化素预示着较大的新生儿出生体重;GDM孕母体内趋化素与血脂水平相关,且可望作为评价妊娠期糖尿病肾功能的指标。
Objective: To investigate the relationship between serum chemokine chemokine and maternal lipids, renal function and neonatal birth weight in maternal and neonatal blood. Methods: Sixty - three patients with gestational diabetes mellitus (GDM) and 64 healthy controls were selected to detect the indexes of maternal blood and umbilical cord blood chemokines, serum lipids, creatinine, urea nitrogen and uric acid. Results: The levels of maternal blood and cord blood chemokines, mother’s total cholesterol (TC) and triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in GDM group were significantly higher than those in control group Cord blood chemokines had a positive correlation with newborn birth weight (r = 0.456, P <0.001). Multiple regression analysis showed that newborn birth weight (β = 0.221, P = 0.012), cord blood chemotaxis (β = 0.289 (P = 0.001), creatinine (β = 0.260, P = 0.001), triglyceride (β = 0.348, P = 0.001), HDL-C Independently associated with maternal chemokines. CONCLUSIONS: GDM maternal chemokines are associated with cord blood chemokines; higher concentrations of chemokines in cord blood are predictive of larger newborn birth weights; chemokines in GDM mothers are associated with lipid levels and It is expected to be used as an indicator of renal function in gestational diabetes mellitus.