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为阐明苯的多发致癌性及其剂量－反应关系，在原１２城市调查基础上扩大队列，并将随访期从１９８１年延长至１９８７年，共调查苯作业工人７４８２８人，对照工人３５８０５人，合计达１２０万人年。共搜集空气苯浓度评价数据１８４３５个。结果表明：苯组白血病、骨髓增生异常综合征（ＭＤＳ）及淋巴瘤发病危险度均显著升高，其中急性髓细胞白血病（ＡＭＬ）的相对危险度（ＲＲ）为３．１，淋巴瘤为３．５；ＡＭＬ、ＡＭＬ与ＭＤＳ和淋巴瘤随累积接苯量增加而升高，呈明显剂量－反应关系。苯接触男工肺癌死亡ＲＲ也显著升高并呈剂量－反应关系。引发肿瘤升高的苯浓度约为３．３ｍｇｍ－３／ａ。
To clarify the carcinogenicity of benzene and its dose-response relationship, the cohort was expanded on the basis of the original 12 urban surveys and the follow-up period was extended from 1981 to 1987. A total of 74,828 benzene workers and 35,805 workers were surveyed, 1.2 million years. Total collection of air benzene concentration evaluation data 18435. The results showed that the risk of benign leukemia, myelodysplastic syndrome (MDS) and lymphoma were significantly increased, with the relative risk of acute myeloid leukemia (AML) of 3.1 and lymphoma of 3 .5; AML, AML, MDS and lymphoma increased with the cumulative amount of benzene increased, showing a significant dose-response relationship. Mortality from benzene exposure to male workers with lung cancer was also significantly increased RR and dose-response relationship. The benzene concentration that causes the tumor to rise is about 3.3 mgm-3 / a.