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苦参总黄酮自苦参根提得,约含0.3％。给小鼠尾静脉注射LD_(50)为103.1±7.66 g/kg。 按Lawson氏法选择吸入氯仿产生心室纤颤阳性率达80％以上的小鼠(体重25～30 g),进行实验。静注苦参总黄酮后,对小鼠吸入氯仿所致心室纤颤有明显地对抗作用,其ED_(50)为28.9±1.1 g/kg,治疗指数为3.56。在同样条件下,硫酸奎尼丁的治疗指数为2.89。 给家兔静注苦参总黄酮8 g和30 g/kg,30～60分钟后,能明显对抗氯仿-肾上腺素引起的心律失常。完全对抗率分别为40％和70％。 给大鼠静注乌头碱引起心律失常,静注苦参总黄酮20～40g/kg,有明显地治疗作用。第一次治疗的有效率达63％,第二次治疗的有效率为84％。 给麻醉大鼠静脉注射苦参总黄酮30 g/kg和60 g/kg,呈现明显地负性自律性作用,负性频率作用和负性传导作用。这些作用随剂量的增加而增强。它们可能是治疗心律失常的药理基础。
Sophora flavescens total flavonoids from bitter roots, about 0.3%. The mice were injected with LD_ (50) at the tail vein of 103.1 ± 7.66 g / kg. According to Lawson’s method, inhalation of chloroform was selected to produce mice with a positive rate of ventricular fibrillation of more than 80% (body weight 25-30 g) for experiments. After intravenous injection of total flavonoids of Sophora flavescens, the antagonism of ventricular fibrillation induced by chloroform inhalation in mice was obvious, with an ED 50 of 28.9 ± 1.1 g / kg and a therapeutic index of 3.56. Under the same conditions, the therapeutic index of quinidine sulphate was 2.89. To rabbits intravenous injection of flavescens total flavonoids 8 g and 30 g / kg, 30 to 60 minutes, can be significantly opposed to chloroform - adrenaline-induced arrhythmia. Full confrontation rates were 40% and 70% respectively. Aconitine intravenous injection to rats caused by arrhythmia, intravenous Sophora flavescens total flavonoids 20 ~ 40g / kg, a significant therapeutic effect. The first treatment was effective at 63% and the second treatment at 84%. To anesthetized rats intravenous injection of total flavonoids of Sophora flavescens 30 g / kg and 60 g / kg, showed a significant negative self-regulatory role, negative frequency and negative conduction. These effects increase with dose. They may be the pharmacological basis for the treatment of arrhythmias.