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本文摹拟临床情况,先从腹腔然后再从静脉注射大肠杆菌死菌,以复制肺损伤的动物模型。结果发现,腹腔十静注者肺损伤比相同剂量单次静注者严重。表现在兔支气管一肺泡灌洗液中白细胞总数、相对通透指数显著增加(P<0.01),中性粒细胞数及白蛋白含量增加(0.05>P>0.01),小鼠累积死亡率增加,形态学改变亦显著。本文说明,腹腔十静注引起的肺损伤更适合成人呼吸窘迫综合征动物实验研究的需要。
This article is to simulate the clinical situation, first from the abdominal cavity and then by intravenous injection of Escherichia coli bacteria, to replicate animal models of lung injury. As a result, it was found that lung injury in the abdominal cavity was severer than that in the same dose intravenously. The total leukocyte count and relative permeability index in the bronchoalveolar lavage fluid were significantly increased (P<0.01), and the number of neutrophils and albumin were increased (0.05>P>0.01). The cumulative mortality of the mice was increased. Morphological changes are also significant. This article shows that the intra-abdominal injection of lung injury caused by intravenous injection is more suitable for the needs of experimental animal studies of adult respiratory distress syndrome.