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目的 探讨电刺激小脑治疗对急性脑梗塞患者血浆内皮素水平的影响。方法 将6 0例急性脑梗塞患者 ,随机分为电刺激小脑治疗组 (30例 )和常规治疗对照组 (30例 ) ,分别观察其疗效和治疗前后血浆内皮素 (ET)含量的变化 ,并与 30名健康人的血浆ET水平进行比较。结果 脑梗塞患者的血浆内皮素水平 (6 1.76± 34 .6 0 )ng/L ,明显高于健康人 (44 .48± 6 .41)ng/L ,P <0 .0 1。电刺激小脑治疗组治疗前与对照组血浆内皮素水平差异无显著性 (P >0 .0 5 ) ;治疗后患者血浆内皮素水平 (39.12± 2 1.39)ng/L ,较对照组 (6 1.5 0± 12 .6 4)ng/L明显降低 (P <0 .0 1) ,与健康人比较差异无显著性 (P >0 .0 5 )。对照组治疗前后差异无显著性 (P >0 .0 5 )。结论 电刺激小脑治疗对急性脑梗塞患者有明显疗效 ,利于患者的早期肢体功能恢复 ,血浆ET水平的降低是其治疗机制之一。
Objective To investigate the effects of electrical stimulation of cerebella on plasma endothelin in patients with acute cerebral infarction. Methods Sixty patients with acute cerebral infarction were randomly divided into three groups: electro-stimulated cerebella treatment group (30 cases) and conventional treatment control group (30 cases). The therapeutic effect and the change of plasma endothelin (ET) Plasma levels of ET in 30 healthy people were compared. Results The level of plasma endothelin (6 1.76 ± 34. 60) ng / L in patients with cerebral infarction was significantly higher than that in healthy people (44.48 ± 6 .41) ng / L, P <0.01. The level of plasma endothelin was not significantly different between the pretreatment group and the control group (P> 0.05). After treatment, the level of plasma endothelin (39.12 ± 2.13) ng / L in the cerebellum-treated group was significantly higher than that in the control group 0 ± 12. 64) ng / L was significantly lower (P <0. 01), compared with healthy people no significant difference (P> 0.05). There was no significant difference in the control group before and after treatment (P> 0.05). Conclusion Electrical stimulation of cerebellum has obvious curative effect on patients with acute cerebral infarction, which is beneficial to the early recovery of limb function and the reduction of plasma ET level.