比较了国产加热灭活乙肝血源疫苗接种新生儿的免疫原性、安全性以及与ＨＢＩＧ联用阻断ＨＢｓＡｇ和ＨＢｅＡｇ双阳性孕妇ＨＢＶ母婴传播的保护效果。结果表明加热灭活乙肝疫苗安全性良好，免后抗ＨＢｓ水平优于月剂量化学灭活乙肝疫苗，其阴断ＨＢＶ母婴传播的保护率与同剂量化学灭活乙肝疫苗无显著性差异。由于加热灭活乙肝疫苗生产成本较低，对乙肝疫苗计划免疫的实施，具有重要的实用价值 The immunogenicity and safety of domestic neonates vaccinated with hepatitis B virus were compared, and the protective effect of HBIG combined with HBIG in blocking mother-to-child transmission of HBsAg and HBeAg-positive pregnant women was also compared. The results showed that the heat-inactivated hepatitis B vaccine was safe and the anti-HBs level was better than the monthly dose of chemical inactivated hepatitis B vaccine. There was no significant difference in the protection rate between the maternal and neonatal hepatitis B virus and the same dose of chemical inactivated hepatitis B vaccine. Due to the lower cost of heat-inactivated hepatitis B vaccine, it is of great practical value to implement the planned hepatitis B vaccine immunization