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1996年,美国全国多发性硬化协会(US National Multiple Sclerosis Society,NMSS)的临床试验建议委员会(Advisory Committee on Clinical Trials in Multiple Sclerosis)根据对多发性硬化(multiple sclerosis,MS)专家的调查问卷确立了MS基于病程的临床分型,旨在明确自然史和人口学研究的亚组定义、促进临床试验受试者的均质化纳入以及在医生和MS患者之间的明确交流[1],确定了复发缓解型(RRMS)、继发进展型(SPMS)、原发进展型和进展复发型四种类型并给出了良性
In 1996, the Advisory Committee on Clinical Trials in Multiple Sclerosis in the US National Multiple Sclerosis Society (NMSS) established a questionnaire based on a survey of multiple sclerosis (MS) specialists Based on the clinical course of the disease course, MS aims to define a subset of natural history and demographic studies, to facilitate homogenization of clinical trial participants, and to establish a clear communication between physicians and MS patients [1] Recurrence Remission (RRMS), Secondary Progressive (SPMS), Primary Progressive, and Progressive Recurrence Four types are given and benign