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本文研究了四氯苯醌与磺胺甲基异口恶唑的荷移反应。实验表明:四氯苯醌与磺胺甲基异口恶唑在硼砂介质中可形成π—π*荷移络合物,络合物的最大吸收波长为365nm,表现摩尔吸光系数是4.83×104L·ml-1·cm-1,络合物组成比为1∶1,比尔定律的线性范围为1.8~33μg/mL,回归方程为A=-6.6×10-3+0.6868V,相关系数r=0.9993,在此基础上初步探讨了荷移反应的机理,并用拟定的方法测定了复方新诺明片剂中磺胺甲基异口恶唑的含量,结果令人满意。
In this paper, the charge transfer reaction of chloranil and sulfamethoxazole was studied. Experiments show that: chloranil and sulfamethoxazole in borax medium can form π-π * charge-transfer complex, the maximum absorption wavelength of the complex was 365nm, the molar absorption coefficient was 4.83 × The linear range of Beer’s Law was 1.8 ~ 33μg / mL, the regression equation was A = -6.6 × 10-3 + 0.6868V, The correlation coefficient r = 0.9993. On this basis, the mechanism of charge transfer reaction was preliminarily studied. The content of sulfamethoxazole in the compound cotrimoxazole tablets was determined by the proposed method, and the results were satisfactory.