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目的探讨生长抑素、奥曲肽治疗急性上消化道出血的疗效。方法 186例急性上消化道出血患者,随机分为对照组、奥曲肽组和生长抑素组,各62例。对照组采用常规泮托拉唑治疗,奥曲肽组采用泮托拉唑与奥曲肽联合治疗,生长抑素组采用泮托拉唑与生长抑素联合治疗,观察三组临床治疗效果及不良反应。结果奥曲肽组、生长抑素组治疗后总有效率分别为98.39%、96.77%,显著高于对照组的77.42%,比较差异均有统计学意义(P<0.05)。对照组、奥曲肽组、生长抑素组患者不良反应发生率分别为12.90%、9.68%、11.29%,比较差异无统计学意义(P>0.05)。结论生长抑素、奥曲肽治疗急性上消化道出血均具有一定的效果,不良反应少,临床应用价值高。
Objective To investigate the effect of somatostatin and octreotide on acute upper gastrointestinal bleeding. Methods A total of 186 patients with acute upper gastrointestinal bleeding were randomly divided into control group, octreotide group and somatostatin group, with 62 cases in each group. The control group was treated with conventional pantoprazole, the combination of pantoprazole and octreotide in the octreotide group, the combination of pantoprazole and somatostatin in the somatostatin group, and the clinical effects and adverse reactions in the three groups were observed. Results The total effective rates of octreotide and somatostatin were 98.39% and 96.77%, respectively, which were significantly higher than those of the control group (77.42%, P <0.05). The incidences of adverse reactions in the control group, octreotide group and somatostatin group were 12.90%, 9.68% and 11.29%, respectively, with no significant difference (P> 0.05). Conclusion Somatostatin and octreotide have some effects in the treatment of acute upper gastrointestinal hemorrhage with few adverse reactions and high clinical value.