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目的探讨丙型肝炎患者血清丙型肝炎病毒核糖核酸(HCVRNA)含量和丙氨酸氨基转移酶(ALT)水平与干扰素治疗效果的关系。方法应用荧光定量聚合酶链反应(FQ—PCR)测定HCV RNA的含量,速率法测定血清ALT水平,测定了16例丙型肝炎患者α-干扰素治疗前和治疗三个月、治疗六个月的HCV RNA含量和ALT水平。结果16例丙型肝炎患者经治疗三个月和六个月HCVRNA含量和ALT水平均显著下降(P<0.05)。经六个月治疗有11例患者(68.8%)HCVRNA含量很低或为零,ALT正常,视为干扰素完全反应者;另外5例为部分及无效反应者。结论FQ—PCR定量准确,用其测定血清HCVRNA含量合并血清ALT水平一起作为丙型肝炎疗效观察指标,对临床制定合理的治疗方案有重要意义。
Objective To investigate the relationship between serum hepatitis C virus RNA (HCVRNA) and the level of alanine aminotransferase (ALT) in patients with hepatitis C and the effect of interferon treatment. Methods The content of HCV RNA was determined by fluorescence quantitative polymerase chain reaction (FQ-PCR). The serum ALT level was measured by the rate method. Sixteen patients with hepatitis C were treated with α-interferon for three months before treatment and six months HCV RNA content and ALT levels. Results The HCV RNA content and ALT level in 16 patients with hepatitis C were significantly decreased at three months and six months after treatment (P <0.05). Eleven patients (68.8%) underwent six months of treatment with low or no HCVRNA, normal ALT, and complete interferon response; the other five were partially and ineffective. Conclusion FQ-PCR quantitative and accurate, with its serum HCVRNA levels combined with serum ALT levels as indicators of efficacy of hepatitis C, to develop a rational clinical treatment programs of great significance.