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文章报道了N,N＇-乙撑-双(L-半胱氨酸乙酯)(ECD)及其衍生物MCD、n-PCD、n-PCD、t-BCD的合成、放化研究结果。ECD及其衍生物的物理常数和光谱数据与结构一致。ECD及其衍生物与~(99m)TC-GH进行配体交换,能与~(99m)Tc(V)生成稳定的络合物,标记率为85—95％,它们的分配系数及HPLC的保留时间证实锝络合物酯溶性大小与酯基的碳原子个数呈正相关。
The synthesis and radiochemical results of N, N’-ethylene-bis (L-cysteine ethyl ester) (ECD) and its derivatives MCD, n-PCD, n-PCD and t- The physical constants and spectral data of the ECD and its derivatives are consistent with the structure. ECD and its derivatives with ~ (99m) TC-GH ligand exchange, with 99m Tc (V) to generate stable complexes with a labeling rate of 85-95%, their partition coefficients and HPLC The retention time confirms that the solubility of the technetium complex is positively correlated with the number of carbon atoms in the ester group.