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采用单盲、随机、安慰剂对照法，研究丽珠欣乐（单硝酸异山梨醇酯）对冠心病心绞痛患者心电图负荷试验阳性者运动耐量的影响。口服本品１０ｍｇ可明显降低运动时血压和心率，在相当于服药前运动最大负荷时可使收缩压下降９．１％±９．３％（Ｐ＜０．０５），舒张压下降１６．５％±７．２％（Ｐ＜０．０１），降低心率１５．７％±１２．２％（Ｐ＜０．０１），血压心率乘积下降２２．５％±１５．１％（Ｐ＜０．０１），减少运动时ＳＴ段下降可达４５．７％±１３．７％（Ｐ＜０．０５），最大工作负荷增加３３．６％±１７．５％（Ｐ＜０．０１），运动时间增加３７．５％±１６．２％（Ｐ＜０．０１），作功总量增加８５．３％±３４．４％。服用维生素Ｃ的病人用药前后则无明显变化。
A single-blind, randomized, placebo-controlled study was performed to determine the effect of Livzon (Isosorbide Mononitrate) on exercise tolerance in patients with coronary heart disease with angina pectoris. Oral 10mg can significantly reduce blood pressure and heart rate during exercise, the equivalent of maximum exercise load medication before the systolic blood pressure decreased by 9.1% ± 9.3% (P <0.05), diastolic blood pressure decreased by 16.5 % ± 7.2% (P <0.01), decreased heart rate by 15.7% ± 12.2% (P <0.01) and decreased by 22.5% ± 15.1% (P <0.05), and the maximum working load increased by 33.6% ± 17.5% (P <0.01), while the decrease of ST segment decreased by 45.7% ± 13.7% Exercise time increased by 37.5% ± 16.2% (P <0.01), total work increased by 85.3% ± 34.4%. Patients taking vitamin C before and after treatment there was no significant change.