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目的对比囊胚培养结合单囊胚移植(eBC-SBT)与卵裂期双胚胎移植在体外受精-胚胎移植(IVF-ET)周期治疗中的临床效果。方法回顾性分析2014年5月—2016年4月在唐山市妇幼保健院生殖中心接受IVF-ET治疗的不孕患者1 272对,均为移植双胚胎具有高风险双胎妊娠可能性的患者,对其进行一对一充分沟通,根据患者意向分为卵裂期双胚胎移植组(A组)和单囊胚移植组(B组),分析二组间的临床妊娠率、种植率、多胎率等。结果单囊胚移植组的种植率高于卵裂期移植组(52.27%vs32.94%,P<0.05),临床妊娠率略降低(50.76%vs 55.95%,P>0.05),但单囊胚移植的多胎率明显降低(1.49%vs 23.58%,P<0.05),早产儿、低体重儿出生率降低(P<0.05),足月单胎活产率提高(P<0.05)。结论囊胚培养结合单囊胚移植相对与传统的卵裂期双胚胎移植能够得到较好的临床妊娠率,同时降低多胎率,能够改善临床妊娠结局。
Objective To compare the clinical effects of blastocyst culture combined with single blastocyst transplantation (eBC-SBT) and cleavage stage double embryo transfer in IVF-ET cycles. Methods A retrospective analysis of 1 272 pairs of infertility patients who received IVF-ET treatment at the Reproductive Center of Tangshan MCH from May 2014 to April 2016 was performed in both patients with high probability of twin pregnancy. The patients were divided into two groups: group A (cleavage embryo transfer) and group B (group B). The clinical pregnancy rate, implantation rate, multiple pregnancy rate Wait. Results The implantation rate of single blastocyst transplantation group was higher than that of cleavage stage transplantation group (52.27% vs 32.94%, P <0.05), and the clinical pregnancy rate was slightly lower (50.76% vs 55.95%, P> 0.05) The multiple birth rate was significantly lower in transplant recipients (1.49% vs 23.58%, P <0.05). The birth rates of premature children and low birth weight children were decreased (P <0.05), and the live birth rate of full term was increased (P <0.05). Conclusions The blastocyst culture combined with single blastocyst transplantation can achieve better clinical pregnancy rate and reduce the multiple pregnancy rate as compared with the traditional double cleavage embryo transfer, which can improve the clinical pregnancy outcome.