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目的 比较直线加速器产生的 6 MVX线与 Co6 0 γ射线治疗鼻咽癌的近期疗效与急性放射性损伤。方法 对 2 0 0例鼻咽癌患者随机分为 6 MVX线治疗组及 Co6 0 治疗组 ,两组设野范围、放射剂量一致 ,观察疗效和副反应。结果 2 0 0例中失访 1 5例 ,随访率 92 .5 %。 6 MVX线组与 Co6 0组两组肿瘤完全缓解率无明显差异 (P=0 .2 4 1 )。两组 2年生存率分别为 85 .71 %及 90 .0 %。 (P=0 .73) ;2年局部控制率为 89.4 7%及 93.75 % (P=0 .38) ,均无显著性差异 ;6 MVX线产生的急性放射性口腔炎及皮炎等副反应较 Co6 0大 (P=0 .0 5 3)。结论 高能加速器产生的 6 MVX线与 Co6 0 治疗鼻咽癌 ,两组近期疗效相仿 ;6 MVX线产生的急性放射反应较 Co6 0 大些
Objective To compare the short-term curative effect and acute radiation injury of nasopharyngeal carcinoma treated by 6 MVX line and Co6 0 γ-ray produced by linear accelerator. Methods Two hundred and ten patients with nasopharyngeal carcinoma were randomly divided into 6 MVX line treatment group and Co60 treatment group. The two groups were set up in the same field and the radiation dose was the same. The curative effect and side effect were observed. Results One hundred and five cases were lost in follow-up, with a follow-up rate of 92.5%. There was no significant difference in complete remission rate between 6 MVX group and Co6 0 group (P = 0.241). The two-year 2-year survival rates were 85.71% and 90.0% respectively. (P = 0.73). The two-year local control rates were 89.4 7% and 93.75% (P = 0.38), respectively. There was no significant difference between the two groups. The adverse reactions such as acute radiation stomatitis and dermatitis 0 big (P = 0 .0 5 3). Conclusions The 6 MVX line produced by high-energy accelerator is similar to Co6 0 in the treatment of nasopharyngeal carcinoma. The short-term curative effect is similar in both groups. The acute radiation response produced by MVX line is larger than that of Co60