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目的:研究榄香烯注射液联合放化疗治疗鼻咽癌及对患者血清VEGF及nm23H1的影响。方法:从2012年7月—2013年7月,选择我院经病理活检后被确诊为鼻咽癌的患者86例作为研究对象。以数字法随机分成观察组(43例)和对照组(43例),对照组予以常规放化疗治疗,观察组在此基础上另予以榄香烯注射液治疗,对比两组近期疗效和局控率及生存率情况,以及VEGF及nm23H1基因mRNA在治疗前后表达水平情况。结果:观察组的总有效率为88.37%(38/43),显著高于对照组的67.44%(29/43),差异均有统计学意义(均P<0.05)。观察组的3年局控率于生存率分别为53.49%(23/43)与46.51%(20/43),均分别显著高于对照组的32.56%(14/43)与25.58%(11/43),差异均有统计学意义(均P<0.05)。观察组治疗后的nm23H1水平为(188.56±21.43)nk/mL,显著高于对照组治疗后的(101.74±24.52)nk/mL;观察组治疗后的VEGF水平为(169.26±82.56)μmol/L,显著低于对照组治疗后的(195.00±18.51)μmol/L,差异均有统计意义(均P<0.05)。结论:以榄香烯联合放化疗对鼻咽癌患者进行治疗,可使患者获得较好预后,其效果显著,值得临床推荐。
Objective: To study the effect of elemene injection combined with radiotherapy and chemotherapy on nasopharyngeal carcinoma and its effect on serum VEGF and nm23H1. Methods: From July 2012 to July 2013, 86 patients diagnosed with nasopharyngeal carcinoma after pathological biopsy in our hospital were selected as study subjects. They were randomly divided into an observation group (43 cases) and a control group (43 cases). The control group was treated with conventional radiotherapy and chemotherapy. The observation group was additionally treated with Elemene injection on the basis of the results. The rate and survival rate, and the expression level of VEGF and nm23H1 mRNA before and after treatment. Results: The total effective rate of the observation group was 88.37% (38/43), which was significantly higher than that of the control group (67.44% (29/43). The difference was statistically significant (all P<0.05). The three-year control rate in the observation group was 53.49% (23/43) and 46.51% (20/43), respectively, which were significantly higher than the 32.56% (14/43) and 25.58% of the control group (11/ 43), the differences were statistically significant (all P<0.05). After treatment, the nm23H1 level in the observation group was (188.56±21.43) nk/mL, which was significantly higher than that in the control group (101.74±24.52) nk/mL; the VEGF level in the observation group after treatment was (169.26±82.56) μmol/L. Significantly less than (195.00±18.51) μmol/L after treatment in the control group, the differences were statistically significant (all P<0.05). Conclusion: The treatment of nasopharyngeal carcinoma patients with elemene combined with chemoradiation can make the patients have better prognosis. The effect is significant and worthy of clinical recommendation.