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目的:观察静脉注射阿魏酸钠协同治疗慢性肾功能衰竭的临床疗效。方法:2011-03-2014-02本院收治的82例慢性肾功能衰竭患者,随机分为治疗组和对照组各41例。对照组采用临床常规治疗;治疗组在对照组治疗基础上加用阿魏酸钠0.3g加入生理盐水250ml中静脉滴注,1次/天。3周后观察比较两组血肌酐(Scr)、血尿素氮(BUN)、内生肌酐清除率(Ccr)变化的差异。结果:治疗组和对照组治疗前BUN、Scr、Ccr值两组间差异无统计学意义(P>0.05);治疗组治疗后BUN、Scr下降及Ccr上升均较对照组明显(P<0.05)。治疗组临床总有效率为88.00%,对照组为57.00%,治疗组明显高于对照组(P<0.05)。结论:阿魏酸钠静脉滴注协同治疗慢性肾功能衰竭可明显改善肾功能,提高临床总有效率。
Objective: To observe the clinical efficacy of intravenous sodium ferulate in the treatment of chronic renal failure. Methods: 82 patients with chronic renal failure admitted to our hospital from March 2011 to April 2014 were randomly divided into treatment group (n = 41) and control group (n = 41). The control group with clinical routine treatment; the treatment group in the control group based on the treatment with sodium ferulate 0.3g added saline 250ml intravenous infusion, 1 time / day. After 3 weeks, the differences of serum creatinine (Scr), blood urea nitrogen (BUN) and endogenous creatinine clearance (Ccr) between the two groups were observed and compared. Results: There was no significant difference in BUN, Scr and Ccr between the treatment group and the control group before treatment (P> 0.05). The BUN, Scr and Ccr in the treatment group were significantly higher than those in the control group (P <0.05) . The total clinical effective rate was 88.00% in the treatment group and 57.00% in the control group, which was significantly higher in the treatment group than in the control group (P <0.05). CONCLUSION: Intravenous sodium ferulate can effectively improve renal function and improve overall clinical efficiency in patients with chronic renal failure.