为提高治疗抗药性恶性疟的治愈率和消除配子体，作者选择了口服双氢青蒿素咯萘啶组合联用。于 １９９６ 年秋，在海南省对氯喹及哌喹的抗性率分别为８０％ 和７０％ 的恶性疟流行区，进行治疗恶性疟的初步观察。双氢青蒿素总剂量２００ｍ ｇ，咯萘啶８００ｍ ｇ，均等分２ 剂，间隔１２－ ２４ｈ服第二剂。共治恶性疟 １０ 例，平均退热时间为２３１±１２７ｈ；无性体原虫平均转阴时间为 ３４４±１００ｈ；药后追踪观察２８ｄ，其中７ 例追踪 ４０ｄ，均未见原虫复燃。治前查见配子体低密度的１ 例，高密度的２ 例，分别于药后ｄ３，ｄ１４ 及 ｄ２０转阴。结果表明，本治疗方案疗程短、治愈率高、可消除配子体，很有前景 In order to improve the cure rate of drug-resistant falciparum malaria and eliminate the gametophyte, the authors chose oral combination of dihydroartemisinin-pyronaridine. In the autumn of 1996, a preliminary observation was conducted on the treatment of P. falciparum in Hainan Province where the resistance rates to chloroquine and piperacillin were 80% and 70%, respectively. Dihydroartemisinin a total dose of 200m g, pyronaridine 800m g, equally divided into two doses, an interval of 12 - 24h service second dose. A total of 10 cases of falciparum malaria were treated with an average of 231 ± 127 hours of fever. The mean time for the elimination of protozoal was 344 ± 100 h. After the drug was observed for 28 days, 7 of them were followed up for 40 days See protozoa resurgence. One patient with low density of gametophyte and 2 patients with high density were examined before treatment, and d3, d14 and d20 turned negative after dosing. The results show that the treatment regimen short course, high cure rate, eliminate gametocytes, very promising